CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome
نویسندگان
چکیده
منابع مشابه
CRY2 Genetic Variants Associate with Dysthymia
People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that interacts with CRY2, in relation to depressive and anxiety disorders. Of these three genes, 48 single-nucleotide polymorphisms (SNPs) whose selecti...
متن کاملDeregulated expression of cry1 and cry2 in human gliomas.
Growing evidence shows that deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of gene chnages controlling circadian rhythm in glioma cells have not been explored. Using real time polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock ge...
متن کاملLight-independent role of CRY1 and CRY2 in the mammalian circadian clock.
Cryptochrome (CRY), a photoreceptor for the circadian clock in Drosophila, binds to the clock component TIM in a light-dependent fashion and blocks its function. In mammals, genetic evidence suggests a role for CRYs within the clock, distinct from hypothetical photoreceptor functions. Mammalian CRY1 and CRY2 are here shown to act as light-independent inhibitors of CLOCK-BMAL1, the activator dri...
متن کاملA putative flavin electron transport pathway is differentially utilized in Xenopus CRY1 and CRY2
Xenopus laevis cryptochromes (xCRYs) can suppress xCLOCK/xBMAL1-mediated activation of a period E box-containing promoter. This suppression is a crucial part of the vertebrate circadian oscillator. Similar to CRYs in other species, as well as to the closely related photolyases, xCRYs have a conserved flavin binding domain. We show here that an intact flavin binding domain is required for normal...
متن کاملA Coupled Stochastic Model Explains Differences in Circadian Behavior of Cry1 and Cry2 Knockouts
In the mammalian suprachiasmatic nucleus (SCN), a population of noisy cell-autonomous oscillators synchronizes to generate robust circadian rhythms at the organism-level. Within these cells two isoforms of Cryptochrome, Cry1 and Cry2, participate in a negative feedback loop driving circadian rhythmicity. Previous work has shown that single, dissociated SCN neurons respond differently to Cry1 an...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 2014
ISSN: 0916-9636,1348-4214
DOI: 10.1038/hr.2014.157